For example, the Ras/Raf/MEK/ERK pathway activated in breast cancer MCF-7 cells can induce binding of Noxa (a BH3-only protein) to Mcl-1 (a Bcl-2 family member) such that Beclin1 is derived from Mcl-1 on the dissociation [236]. The gene discussed is MCL1; the disease is breast cancer.