In this regard, particularly in breast cancers, while insulin and insulin analogues used to treat diabetes propagated tumor growth through the induction of angiogenesis and activation of mitogenic signaling mechanisms and drugs such as thiazolidinediones do not appear to have a significant anti-cancer effect, metformin on the other hand exhibited significant anti-proliferative and anti-cancer effects [5]. This evidence concerns the gene INS and breast carcinoma.