CCND1 and breast carcinoma: Increase in the levels of Raptor, C-Raf, Cyclin B1, Cyclin D1, TRFC, and Syk; while reduction in the levels of pMAPKpT202, Y204, JNKpT183, pT185, BadpS112, PKCαpS657, and SrcpY416 was observed in the metformin administered (1500 mg, daily, NCT00930579, phase II, Table 2) non-diabetic overweight women with breast cancer when compared to age, BMI, and stage-matched historic controls [159].