A gain-of-function missense mutation in AKT2, Glu17Lys (E17K), is the cause of a hypoinsulinemic hypoketotic hypoglycemia, which is also a rare genetic disease in which there is constitutive expression of AKT2, leading to severe hypoglycemia, hypoinsulinemia, and increased body fat [3]. The gene discussed is AKT2; the disease is Hypoinsulinemia.