NLRP3 and early-onset autosomal dominant Alzheimer disease: Nevertheless, NLRP3 inflammasome activation has been recently associated with various pathological conditions such as gout, diabetes, chronic kidney diseases including podocyte damage and glomerular injury [17, 23–25, 27–30, 32, 33] and to a number of other diseases like acute lung injury, silicosis, Alzheimer’s disease, liver toxicity, and cystic fibrosis [22–25, 27, 28].