IL10 and colitis: A lead, first-in-class molecule, PH46A, 6-(methylamino)hexane-1,2,3,4,5-pentanol-4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1′H-[2,2-biinden]-2-yl) methyl) benzoate [8,9] has been shown to have a biological effect in two different well-established preclinical models of murine colitis: the acute dextran sodium sulphate model and the chronic and spontaneous Interleukin-10 (IL-10−/−) knock-out mouse model [8].