A possible explanation for development of resistance to androgen‐directed therapies is the existence of cancer stem cells, which were described in detail by Maitland et al.1 They postulate that there is a hierarchy within tumors and that the bulk population of tumor cells is derived from tumor‐initiating cells, which represent a small self‐renewing subpopulation.2 They may belong to the basal compartment of the prostate,1 show no AR expression and thereby are not targeted by conventional therapies.3 The issue of the origin of PCa is still open for discussion. This evidence concerns the gene AR and posterior cortical atrophy.