We repeated these experiments with two independent shRNAs for each gene in both N2N1G and 16T SCLC cells, which confirmed that Gap43 and Fez1 knock-down reduced the formation of liver metastases after intravenous injection of SCLC cells (Figure 4A–H and Figure 4—figure supplement 2D–E). This evidence concerns the gene GAP43 and small cell lung carcinoma.