We repeated these experiments with two independent shRNAs for each gene in both N2N1G and 16T SCLC cells, which confirmed that Gap43 and Fez1 knock-down reduced the formation of liver metastases after intravenous injection of SCLC cells (Figure 4A–H and Figure 4—figure supplement 2D–E). The gene discussed is FEZ1; the disease is small cell lung carcinoma.