In human tumors (George et al., 2015), the 13-gene signature correlated more closely with the ‘SCLC-N’ subtype, driven by the transcription factor NEUROD1, and both human cell line NCI-H446 and the PDX model LU86 (Saunders et al., 2015) belong to this subtype (Figure 3—figure supplement 1C). Here, NEUROD1 is linked to small cell lung carcinoma.