To gain further insights in this observation, we investigated whether reactivity was restricted to the subpopulation of GLAST positive astrocytes, in two different areas of the hypothalamus: The ARC nucleus, involved in the control of food intake and where inflammation and gliosis was linked to obesity in rodents and humans (reviewed in Valdearcos et al., 2015; McNay et al., 2012; Thaler et al., 2012) and the SCN, the main regulator of circadian locomotor activity in mammals (Ralph, Foster, Davis, & Menaker, 1990; Stephan & Zucker, 1972). Here, SLC1A3 is linked to obesity due to melanocortin 4 receptor deficiency.