In the present study a panel of gene mutations (IDH1, IDH2, DNMT3A, SF3B1,and U2AF1), genetically reported to be the important regulator in DNA methylation and RNA spliceosome and highly associated with MDS by recent studies (Adès et al., 2014; Gill, Leung, & Kwong, 2016; Lee et al., 2015; Lin et al., 2011, 2012), was analyzed by HRMA to further explore the correlation of hypomethylated MIR‐378 and genetic changes in MDS. Here, DNMT3A is linked to myelodysplastic syndrome.