In vitro experiment, THP‐1 cells, an AML cell line, treated with a HMA 5‐aza‐dC, exhibited up‐expression of MIR‐378 in a dose‐dependent manner (Xiao‐Wen et al., 2015), providing the evidence of methylation regulation of MIR‐378 in AML cell line (Xiao‐Wen et al., 2015). The gene discussed is MIR378A; the disease is acute myeloid leukemia.