Circadian clock genes (Clock, Bmal1, Cry2, and Per2) were dysregulated in mice with high fat diet induced non‐alcoholic steatohepatitis (NASH), affecting clock‐regulated lipid metabolism proteins (Rev‐Erbα, RORα and SREBP1c) leading to further impairment of lipid metabolism and fatty liver development (Bruce et al., 2016). Here, PER2 is linked to metabolic dysfunction-associated steatohepatitis.