Circadian clock genes (Clock, Bmal1, Cry2, and Per2) were dysregulated in mice with high fat diet induced non‐alcoholic steatohepatitis (NASH), affecting clock‐regulated lipid metabolism proteins (Rev‐Erbα, RORα and SREBP1c) leading to further impairment of lipid metabolism and fatty liver development (Bruce et al., 2016). This evidence concerns the gene NR1D1 and metabolic dysfunction-associated steatohepatitis.