Although liquid chromatography‐tandem mass spectrometry studies in HEK293 cells identified GLTSCR1 as a novel bromodomain protein 4 (BRD4)‐interacting protein, which performed a positive transcription elongation factor b (pTEFb)‐independent transcriptional activation function,13 the model of interaction between GLTSCR1 and BRD4 remains to be clarified, and the importance and biological roles of this complex in various diseases, including cancer, await definition. The gene discussed is BRD4; the disease is cancer.