BICRA and colorectal carcinoma: As an epigenetic reader protein, BRD4 plays an oncogenic role in cancer metastatic processes and clinical stages through binding to acetylated lysine residues on histones.16 To explore whether GLTSCR1 inhibits CRC metastasis through interaction with BRD4, we used shRNA to stably knock down BRD4 expression in wild‐type and GLTSCR1‐KO HCT116 cells (Figure 4E).