However, hosts post undergoing exogenous thymus transplantation may easily develop autoimmune diseases or other immune dysregulations due to incompatibility of alien thymic tissues to recipient innate progenitors.27 Here, it is an innovative report to unravel thymic 3D‐evolution instance from endogenous voided rudiment into panoramic cortex/medulla revival in immune‐deficient/aging hosts via dynamic modulation involved crucially in Clock‐Arntl/Per3‐Tim cascade yet little in foxn1‐related factors. Here, FOXN1 is linked to autoimmune disease.