CD28 and neoplasm: By 200× magnification (Figure 7C) and dynamic immunofluorescence scanning (Figure 7D) for tumor parenchyma of two independent models, plentiful CD4/8/CD28 and Vγ4T‐cell subsets congregating into local tumor nests were monitored in Post‐Balb/cnu/nu, yet very few in Normal Balb/c or Balb/cnu/nu groups as without TCR‐innovated peripheral microenvironment.