Consequently, ETSB could reoriginate molecule clock to reset voided thymic rudiment into endogenous renovation by Clock/Arntl‐Per3/Tim loop re‐priming TECs into MET/EMT dynamic reversion in central microenvironment for thymic progenitors enriched and subjected to systemic innovation toward TCR‐evolving orchestration, with innate‐adaptive defense dynamics revival against progressive biologic burden and tumor challenges. This evidence concerns the gene PER3 and neoplasm.