Indeed, there are over 50 cytokines that signal through JAK‐mediated type I and II receptors,6 many implicated in inflammatory disease pathophysiology.1, 4 Notably, IL‐6 induces acute‐phase proteins such as C‐reactive protein (CRP) and may be involved in the autoimmune process through B‐cell modulation and T‐helper‐17‐cell differentiation.7 Common γc cytokines play a key role in adaptive immune functions, for example, in T‐cell and natural killer (NK)‐cell differentiation.5 JAKs are therefore an attractive therapeutic target for RA and other inflammatory diseases.6 This evidence concerns the gene CRP and rheumatoid arthritis.