Sharma et al. found that IL-8 binds to CXCR1/CXCR2 and indirectly promotes angiogenesis, proliferation, and invasion of cancer cells and promotes the progression of glioblastoma multiforme, and the level of IL-8 is higher and the patient’s prognosis is worse [135]. The gene discussed is CXCL8; the disease is glioblastoma.