After additional adjustment for smoking, marital status, regular exercise, central obesity, self-reported history of hypertension, respiratory diseases, and cancer (Model 2), and after accounting for differences in cognitive status, the association between hs-CRP levels with mortality was slightly more pronounced [HR Q4 vs Q1: 2.10 (95% CI, 1.30, 3.39)] (P-trend< 0.05). This evidence concerns the gene CRP and hypertensive disorder.