CRP and dementia: For example, in a cohort study [16] of oldest-old aged 90 or older with outcomes being total mortality and incidence of dementia, high levels of CRP (the cutoff value was 5.0 mg/L) were associated with greater risk of total mortality [HR: 1.7 (95% CI, 1.0, 2.9)] after adjustment for APOE4 genotype and other risk factors; however, this study did not consider the impact of cognition on the relationship between CRP exposure and mortality.