After further adjustment for traditional cardiovascular risk factors (smoking, BMI, LDL, diabetes, systolic blood pressure and antihypertensive treatment) nine proteins remained significant after correcting for multiple testing (leptin, CCL20, IL-1 receptor antagonist protein, IL-6, matrix metalloproteinase-7, lectin-like oxidized LDL receptor 1, urokinase plasminogen activator surface receptor, matrix metalloproteinase-12, follistatin; corrected p < 0.001, < 0.001, = 0.011, = 0.015, = 0.021, = 0.034, = 0.034, = 0.034, = 0.034, respectively). The gene discussed is LEP; the disease is diabetes mellitus.