The present study showed that SWAP-70 was highly expressed in human high-grade glioma tissues, and high-grade glioma patients with high expression of SWAP-70 in tumor tissues had a poorer prognosis and shorter median survival time compared to those with low SWAP-70 expression, suggesting that SWAP-70 plays an important role in the degree of malignancy of GBs. This evidence concerns the gene SWAP70 and neoplasm.