GRM2 and cancer: The bolded genes in Table 1 (GRM2, CRHR1, CBLN3 and ODF4), which also have a low standard deviation within the control group, could be very important for cancer proliferation.GRM2 codes for L-glutamate, which is one of the major, neurotransmitters in the central nervous system and activates both iono tropic and meta botropic glutamate receptors [21].The gene CRHR1 encodes a G-protein coupled receptor that binds neuro peptides regulating the hypothalamic-pituitary-adrenal pathway [21].