Successive oxidative stress and biochemical changes results in neuronal death and neuritic plaques growth in Alzheimer's disease (AD).Therefore, it is interest to analyze amyloid-βeta precursor protein (APP), beta-secretase 1 (BACE1), presenilin (PSEN1 and PSEN2) genesfrom brain tissues to gain insights. The gene discussed is PSEN1; the disease is early-onset autosomal dominant Alzheimer disease.