In SpA infiltrate areas, the following unique canonical pathways were present such as Role of osteoblasts, osteoclasts and chondrocytes in RA, Axonal guidance signaling, Virus entry via endocytic pathways, Leukocyte extravasation signaling, CDC42 signaling, CCR5 signaling in macrophages, Role of NFAT in regulation of the immune response and Hepatic fibrosis/hepatic stellate cell activation, again demonstrating significance of non-immune pathogenic mechanisms in SpA even in infiltrate areas. This evidence concerns the gene CDC42 and rheumatoid arthritis.