As for Rap1 signaling pathway:PRKCI-PARD6A-PARD3 LoF simulation analysis related to diabetes, we found up to nodes disturbing the activation of the sub-pathway: CTNNB1, CDH1, RAPGEF1, DOCK4, RAP1GAP, SIPA1L2, SIPA1L1, SRC/FARP2, CDC42, VAV2/TIAM1 and PKKCI/PARD6A/PARD3.Among them, the LoF of nodes RAP1GAP, SIPA1L2 and SIPA1L1 were the only ones showing diabetes-like activation values, therefore resulting in an overactivation of the Rap1 signaling pathway:PRKCI-PARD6A-PARD3 circuit, as found in the analysis performed with the diabetes dataset. The gene discussed is RAPGEF1; the disease is diabetes mellitus.