As illustrated in Fig. 8, these neuromodulatory effects of SCH might be associated with the neuronal polarity (Map1b, Crmp1, Crmp2, Crmp5, Hnrnpa2b1 and Hnrnph1), energy metabolism (Cytb-c1 and Oxct1), protein folding (Hsp75 and Psma6) and neuronal connectivity (Stx1a). Here, CRMP1 is linked to spindle cell hemangioma.