In the present study, we demonstrate for the first time that caveolin-2 (Cav-2), a member of caveolin protein family that is largely dissimilar from its better known cousin, caveolin-1 in their amino acid sequence and function21–25, is critical for lung cancer growth through novel mechanisms involving TAMs and suppression of the anti-tumor immune response. Here, CAV2 is linked to lung carcinoma.