CAV2 and neoplasm: Moreover, the analyses of M1- vs. M2-like TAM subpopulations relative to total cells within the tumor demonstrates a greater increase in M1- compared to M2-like TAMs in the early stage tumors from Cav-2 KO mice, suggesting that considerably higher numbers of M1-like TAMs appear to be critical for tipping the balance from pro-tumor to anti-tumor microenvironment and regression of lung carcinoma tumors in Cav-2 KO mice.