CD4 and neoplasm: However, based on the experimental evidence in this study, we believe that loss of Cav-2 in TAMs rather than in CD4 and CD8 T cells could initiate the anti-tumor immune response involving a combination of tumoricidal effects of M1-polarized TAMs and cytotoxic CD8 T cells leading to lung carcinoma tumor regression observed in Cav-2 KO mice.