The same study also demonstrated that depletion of macrophages with Clodronate significantly reduces β-glucan-mediated therapeutic efficacy, which partially support our data that if we provide more supply rather than depletion of macrophages combined with activated M1 phenotype, the tumors might be eliminated (as it happened in Cav-2 KO mice implanted with lung carcinoma cells). Here, CAV2 is linked to lung carcinoma.