We also stratified AP lesions into active and inactive status, according to the methodology proposed by Menezes et al. 13, and observed that expression of WNT3A and WNT5A was markedly higher in active lesions, while no differences were observed for WNT3 and WNT9B (P > 0.05) (Fig. 2). The gene discussed is WNT3A; the disease is alkaline phosphatase measurement.