However, the diminished recruitment of Beclin1 to the TLR4-receptor complex and the decreased UVRAG-Beclin1-Vps34 assembly/activity in Dox-induced iUVRAGFS mice suggest that the autophagy function of UVRAG is intrinsically required for mitochondrial homeostasis and adequate regulation of inflammasome activation during sepsis. The gene discussed is UVRAG; the disease is Sepsis.