These studies have also identified a number of genes within 12q13-15, including HOXC13, MDM2, HMGA2, CDK4, and CPM, as being key to the development of DDLPS and WDLPS; a number of additional genomic occurrences, such as the loss of 11q23 and the gain of 6q23 and 1p32, have been defined as genomic abnormalities that are specific to DDLPS6,8,11–17. The gene discussed is MDM2; the disease is dedifferentiated liposarcoma.