Some histological types of sarcoma can be characterized by the presence of specific fusion genes, such as EWSR1-FLI in Ewing’s sarcoma23, EWSR1-ATF1 or EWSR1-CREB1 in clear cell sarcoma24, and SS18-SSX1/2 in synovial sarcoma25, all of which function as drivers of tumor development. The gene discussed is CREB1; the disease is sarcoma.