CDH2 and cervical carcinoma: Also, si-circCLK3 increased E-cadherin expression and down-regulated Vimentin and N-cadherin expression, while overexpression of circCLK3 decreased E-cadherin expression and up-regulated Vimentin and N-cadherin expression, indicating that circCLK3 promotes EMT of cervical cancer (Fig. 7d, e).