BMP4 was shown to effectively inhibit the expression of mTOCR1 signaling members, such as S6k, Deptor, Pras40, Rptor, mTor, and Srebf1 at 36h and/or 72h after Ad-B4 infection, while transiently up-regulating the expression of Lipin1 at 36h after Ad-B4 infection (Figure 2D). The gene discussed is AKT1S1; the disease is infection.