TAK1 further induces downstream signaling pathways such as ROS, EGFR, mitogen-activated protein kinases (MAPKs), Akt, and nuclear factor kappa-B (NF-κB) etc. to regulate a number of cellular and clinical events, e.g., tissue inflammation/inflammatory diseases, cell death/tissue homeostasis, rheumatoid arthritis and carcinogenesis/cancer etc. [18–20]. Here, EGFR is linked to cancer.