Similarly as for the H19 DMR—where epigenetic alterations that affect CTCF binding cause the growth-related imprinting disorders Beckwith-Wiedemann Syndrome (BWS) and Silver-Russell Syndrome (SRS) [2]—maternal CTCF binding at the Meg3 DMR is evolutionarily conserved in humans [5]. The gene discussed is MEG3; the disease is Silver-Russell syndrome.