There are two reasons for investigating the potential effects of APOE-ABCA7 interactions on DMN alteration and its associated memory impairment in AD; one is that loss-of-function variants in both APOE and ABCA7 drive Aβ plaque deposition [15, 19], and the other is because the ABCA7 (rs3764650) and APOE-ε4 carrier status show interaction effects on memory [20]. This evidence concerns the gene ABCA7 and memory impairment.