Since evidences have indicated impacts of age, APOE, and sex dimorphism on the risk of AD [43], we further analyzed the interaction effects of APOE-ε4 carriage with sex differences and with age of onset, in which subjects were dichotomized into early onset (before 65 years) or late onset disease (65 years and above) [44], on memory performances. This evidence concerns the gene APOE and Alzheimer disease.