EPHA4 and Alzheimer disease: Western blotting confirmed a strong reduction in cortical and hippocampal EphA4 protein in EphA4flox/flox x Camk2aCre (EphA4-KO) versus EphA4flox/flox (Ctrl) mice and EphA4flox/flox x Camk2aCre x APPPS1 (AD;EphA4-KO) versus EphA4flox/flox x APPPS1 (AD) mice (Fig. 1a–d).