The Ad and Aad rates were lower when compared to insulin alone (Ad, 40.9% and Aad, 18.2%) and metformin alone (Ad, 33.2% and Aad, 15.2%), which suggested combination of metformin and insulin is more effective in reducing CRC risk among the T2DM patients [100]. The gene discussed is INS; the disease is type 2 diabetes mellitus.