CEACAM5 and colorectal carcinoma: CRC patients with metformin intake recorded reduced death percentage (48% versus 76%, P < 0.001), recurrence rate (4% versus 19%, P = 0.002), metastases rate (23% versus 46%, P = 0.001), improved 5-year survival rates (57% versus 37%, P = 0.004), OS years (5.7 versus 4.1, P = 0.007), and enhanced reduction of carcinoembryonic antigen (72% versus 47%, P = 0.015) as compared to non-metformin CRC patients.