Besides, analysis showed that there was a higher proportion of negative expression of NDRG1 when tumor size was > 3 cm (15 and 48 cases of NDRG1 negative expression for size ≤3 cm and size > 3 cm, respectively, p <  0.001), indicating that NDRG1 might be related to tumor proliferation. The gene discussed is NDRG1; the disease is neoplasm.