HDL and its mimetic peptide improved diastolic function in low-density lipoprotein receptor deficient (LDLr(−/−)) mice and cholesterol-fed rabbits respectively [25, 26].However, inflammation leads to impaired anti-inflammatory capacity of HDL and promotes transformation of HDL into pro-inflammatory particles [27].Impaired anti-inflammatory property of HDL was associated with heart failure [28]. This evidence concerns the gene LDLR and heart failure.