However, neither pre-existing type 2 diabetes (n = 65, median 226.6 pmol/l, range 2.1–1871.0 pmol/l, p = 0.196; Fig. 3a) nor obesity (n = 36, median 248.1 pmol/l, range 17.5–1319.0 pmol/l, p = 0.126; Fig. 3b), as defined by a body mass index (BMI) above 30 kg/m2, were associated with MR-proANP plasma concentrations. The gene discussed is NPPA; the disease is obesity due to melanocortin 4 receptor deficiency.