At admission to the ICU, plasma MR-proANP concentrations in the total cohort and the subgroups of sepsis and non-sepsis patients were closely correlated with classical markers of inflammation and bacterial infection, such as C-reactive protein (r = 0.286, p < 0.001), procalcitonin (r = 0.378, p < 0.001), and experimental markers of inflammation such as soluble urokinase plasminogen activator receptor (suPAR, r = 0.493, p < 0.001, Fig. 2c), and NT-proCNP (r = 0.683, p < 0.001, Fig. 2d, Table 3). This evidence concerns the gene NPPA and bacterial infectious disease.