Promoter hypermethylation of SFRP2, co-hypermethylation of SFRP1 and SFRP2, and co-hypermethylation of SFRP1, SFRP2, and WIF1 could be considered as independent prognostic predictors for the survival advantage in patients with CRC. Here, SFRP2 is linked to colorectal carcinoma.