Furthermore, we speculated that lncRNA MALAT1 may be involved in EZH2-mediated phosphorylation of AKT-1, thus affecting the expression and export from the nucleus of BRCA1. The extent of AKT-1 phosphorylation was detected after silencing lncRNA MALAT1 in skeletal muscle cells of sepsis. This evidence concerns the gene MALAT1 and Sepsis.