EZH2 regulated the expression and export from the nucleus of BRCA1 in skeletal muscle cells in sepsis via regulation of the extent of AKT-1 phosphorylation, which was indicated by the fact that silencing EZH2 promoted the expression of BRCA1 in the nucleus and inhibited the expression of BRCA1 in the cytoplasm, which was reversed by treatment of oe-AKT-1. The gene discussed is EZH2; the disease is Sepsis.