FBN1 and Alzheimer disease: To investigate the mechanism by which these two types of FBN1 mutations lead to different clinical phenotypes, we performed HE staining, AB/PAS staining, MASSON staining, SMA staining, and Van Gieson staining on pathological aortic wall specimens obtained from patients who underwent surgery to determine the pathological effects of the different mutation types on the aortic wall between the AD and AA groups (12 patients in AD and 12 patients in AA).