For instance, aloin was reported to enhance the antineoplastic activity of cisplatin B16‐F10 melanoma cells.10 Besides, MET and curcumin combination treatment inhibited the growth, metastasis, and angiogenesis of HCC.19 Rosiglitazone and MET combined to inhibit HCC.20 In present study, we demonstrated that MET in combination with aloin suppress HCC in vitro and in vivo. Here, MET is linked to hepatocellular carcinoma.