Other studies indicated that miR-218 could prevent the cell cycle progression of gastric cancer cells [18], participate in cardiomyocyte hypertrophy via REST [24], and affect chronic obstructive pulmonary disease (COPD) by regulating the TNFR1-mediated activation of NF-κB [26]. Here, NFKB1 is linked to chronic obstructive pulmonary disease.