Drugs used for the treatment of RA are non-steroid anti-inflammatory drugs that have rapid onset of action but do not alter the course of disease, corticosteroids that suppress synovitis and the symptoms of RA, disease modifying anti-rheumatic drugs (DMARDs) and biological agents (biologics), including anti–TNF agents (anti-TNFs) alone or in combination with other options. This evidence concerns the gene TNF and rheumatoid arthritis.