SUMO2 and cancer: Cambogin, a polycyclic polyprenylated acylphloroglucinols (PPAPs) isolated from the branches of Garcinia esculenta (a tropical evergreen tree and traditional cancer treatment across Southern Asia), was identified as a potent and effective inhibitor of KSHV latent and primary infection at a low concentration (nM), as it blocked LANASIM-SUMO2 interaction.