Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14 or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosome is associated with B-progenitor ALL (B-ALL) [7] and Down syndrome-related ALL [8]. The gene discussed is P2RY8; the disease is acute lymphoblastic leukemia.