VEGFA and central nervous system cancer: Based on a postulated change in blood flow dynamics leading to an increased level of OXPHOS due to nutrient depletion rather than higher glycolytic activity driven by hypoxia [17], we chose to study a glioma model as a prototypical system for investigating therapy-driven alternations in tumor metabolism We performed a preliminary study to establish the response rate to anti-VEGF mab B20.4.1.1 in this animal model, followed by longitudinal hyperpolarized [1-13C]Pyruvate imaging study to assess if 48 hr Lac, Bic, tumor size or Lac/Bic levels predicted long-term survival.