Multivariate COX regression with those variables found significant difference only in A09 (HR:0.46, 95 % CI: 0.233-0.889, p =0.021), tumor number (HR: 2.02, 95 % CI: 1.279-3.199, p=0.003), TMD (HR: 1.10, 95 % CI: 1.035-1.177, p=0.003), AFPDAY (HR: 35.35, 95 % CI: 4.203-297.311, p=0.001), GGT(HR: 1.00, 95 % CI: 1.000-1.006, p=0.022), CEA (HR: 1.11, 95 % CI: 1.045-1.186, p=0.001) (Supplementary Table 3). This evidence concerns the gene CEACAM5 and neoplasm.