In parallel, analyses of Mbnl1 mutant mice (Dixon et al., 2015) and evidence that misregulation of MBNL1-splice target gene SCN5A encoding a cardiac sodium channel leads to cardiac arrhythmia and conduction delay (Freyermuth et al., 2016), indicate that Mbnl1 contributes to DM1 heart phenotypes. This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.