Genes inaD and Syn, which were downregulated, encode scaffolding PDZ domain proteins with regulatory functions on TRP Ca2 channels (Shieh and Zhu, 1996; Ueda et al., 2008); their mutations cause cardiac hypertrophy, arrhythmia, and heart block (Spassova et al., 2004). Here, PATJ is linked to cardiac arrhythmia.