TP53 and adenocarcinoma: TP53 is a stress response gene that activates the transcription of numerous downstream genes in response to genotoxic stress, oncogenic signalling, DNA damage and cellular injury.53 The frequency of TP53 mutations is the highest in SQCC and lower in adenocarcinomas among NSCLC tumour samples.54, 55 In our study, we found that dynamic DEGs including MVP and SCP2 were involved in the downstream regulation of TP53.