CD274 and metastatic neoplasm: More recently, Zhang et al13 compared PD‐1 and PD‐L1 expressions (via IHC) in patient‐matched tumors from 165 Asian RCC patients (78% ccRCC) and observed discordant PD‐1 and PD‐L1 across primary and metastatic tumors in lung/lymph node metastases, PD‐L1 in bone metastases, and PD‐1 in brain and viscera metastases.