However, 3–6% of tumours have more than one molecular classifying feature (hereafter referred to as ‘multiple‐classifier’ ECs) 9, 10, 11, 12, and include those with combined POLE exonuclease domain mutation (EDM) and abnormal p53 (POLEmut–p53abn), combined DNA mismatch repair deficiency (MMRd) and abnormal p53 (MMRd–p53abn), combined MMRd and POLE EDM (MMRd–POLEmut), and all three defects (MMRd–POLEmut–p53abn) 9, 10, 11, 12. This evidence concerns the gene POLE and neoplasm.